EST. 2026 · TOKYO / TALLINN

Institute of One
-Medical Imaging AI Research

Institute of One
-Medical Imaging AI Research

The First Agentic AI-Native Research Institute in Medical Imaging

The First Agentic AI-Native Research Institute in Medical Imaging

One Human. A Legion of Agents.

One Human. A Legion of Agents.

A research institute of one.

A research institute of one.

One human directs a legion of AI agents to form a working medical-imaging institute — no campus, no department, no borders.

One human directs a legion of AI agents to form a working medical-imaging institute — no campus, no department, no borders.

We publish the process, not only the results.

We publish the process, not only the results.

The prompts, the decisions, the dead ends, the moments a human overrides the machine — all of it is the record. The process is the contribution.

The prompts, the decisions, the dead ends, the moments a human overrides the machine — all of it is the record. The process is the contribution.

Human-accountable. Agent-accelerated.

Human-accountable. Agent-accelerated.

Every output carries one name and one responsibility: a human author. The agents are credited as tools, in the open. Rigor is never traded for speed.

Every output carries one name and one responsibility: a human author. The agents are credited as tools, in the open. Rigor is never traded for speed.

Built in the open, from anywhere.

Built in the open, from anywhere.

Operating across Japan and Estonia, this is a live experiment in what one person and a legion of agents can build.

Operating across Japan and Estonia, this is a live experiment in what one person and a legion of agents can build.

Shuji Yamamoto, PhD — Founder

Medical imaging researcher (PhD, Health Sciences, Osaka University). Three decades across medical imaging, radiomics, and AI-assisted analysis. Visiting researcher, National Cancer Center Japan · Lecturer in medical imaging & AI, Kochi University School of Medicine. RSNA Certificate of Merit; US and Japanese patents. Accountable for everything published here.

ORCID

Google Scholar

ResearchGate

Lisit Co., Ltd. — CEO

TexelCraft OÜ — CEO

The Fellows are AI agents, not people.

Claude — Chief Research Agent

GPT — Systems Architect

Gemini — Knowledge Analyst

THE LIBRARY

Work is published openly as it happens — Research Notes (IORN), code, and process logs, with DOIs assigned to citable outputs. Everything produced here is a live record of what one person and a legion of agents can build, verify, and share.

Work is published openly as it happens — Research Notes (IORN), code, and process logs, with DOIs assigned to citable outputs. Everything produced here is a live record of what one person and a legion of agents can build, verify, and share.

IORN-001

An Open, Reproducible Gamma-Variate Pipeline for CT-Perfusion Curve Analysis

CODE：https://github.com/Institute-of-One/ctp-core

DOI：https://doi.org/10.5281/zenodo.20921269

PREPRINT：https://www.medrxiv.org/content/10.64898/2026.06.26.26356666v1

IORN-002

A Synthetic Digital Phantom Stability Atlas for IBSI Radiomics Features, with Physics-Based Normalization

CODE：https://github.com/Institute-of-One/radiomics-phantom

DOI：https://doi.org/10.5281/zenodo.21309875

PREPRINT

IORN-003

An Open, Closed-Form-Validated Framework for Task-Based Image Quality on Synthetic Phantoms

CODE：https://github.com/Institute-of-One/taskiq-core

DOI：https://doi.org/10.5281/zenodo.21422924

PREPRINT：under peer review — SPIE Journal of Medical Imaging

IORN-004

An Open-Source, Provenance-Aware Framework for Reconstructing Missing CT Dose Indices from DICOM Metadata

CODE：https://github.com/Institute-of-One/ctdose-core

DOI：https://doi.org/10.5281/zenodo.21636082

PREPRINT：under peer review — Journal of Applied Clinical Medical Physics

Institute of One · Supported by Lisit Co., Ltd. (Japan) & TexelCraft OÜ (Estonia) · instituteofone.org